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Article

Methylation pharmacogenetics: thiopurine methyltransferase as a model system.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2000

Weinshilboum R M

Abstract excerpt

1. Methyl conjugation is an important pathway in the biotransformation of many drugs and xenobiotic compounds. 'Pharmacogenetic' variation exists in the activities of many methyltransferase enzymes, and experiments with the drug-metabolizing enzyme thiopurine methyltransferase (TPMT) offer a model for one approach that has proven useful in the study of methyltransferase pharmacogenetics. 2. TPMT catalyzes the...

Topics

Animals
Genetic Variation
Humans
Methylation
Methyltransferases
Models, Biological
Pharmacogenetics
Polymorphism, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1441597
DOI: 10.3109/00498259209051860

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1441597-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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