Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States.

doi:10.1007/s10549-010-1195-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States.

Breast cancer research and treatment - 1 Apr 2011

Ding Yuan Chun, Steele Linda, Kuan Chih-Jen, Greilac Scott, Neuhausen Susan L

Abstract excerpt

Male breast cancer (MBC) is an uncommon disease with a frequency of approximately one in 1000. Due to the rarity of MBC, it is understudied and its etiology is poorly understood. Our objectives are to determine the frequency of pathogenic mutations in BRCA2 and PALB2 in MBC cases and to investigate the correlations between mutation status and cancer phenotypes. Single strand conformation polymorphism analysis,...

Topics

Adult
Aged
Aged, 80 and over
Breast Neoplasms, Male
Fanconi Anemia Complementation Group N Protein
Genes, BRCA2
Genetic Predisposition to Disease
Genetic Testing
Humans
Lymphatic Metastasis
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Models, Genetic

Mutation

Nuclear Proteins

Tumor Suppressor Proteins

United States

Source

Open in PubMed Open full text

Identifiers

PMID: 20927582
DOI: 10.1007/s10549-010-1195-2
PMCID: PMC3059396

Genes

BRCA2
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States.PMID 20927582Read ↗

Whole-exome sequencing and targeted gene sequencing provide insights into the role of PALB2 as a male breast cancer susceptibility gene.Semantic proximity Read ↗

BRCA and PALB2 mutations in a cohort of male breast cancer with one bilateral case.Semantic proximity Read ↗

Comprehensive Genomic Profiling through Panel-based and Whole-exome Sequencing in a Population-based Chinese Han Male Breast Cancer CohortSemantic proximity Read ↗

Male Breast Cancer: From Molecular Genetics to Clinical ManagementSemantic proximity Read ↗

A novel PALB2 truncating mutation in an Italian family with male breast cancer.Semantic proximity Read ↗

Male breast cancer risk associated with pathogenic variants in genes other than BRCA1/2: an Italian case-control study.Semantic proximity Read ↗

The molecular genetic make-up of male breast cancerSemantic proximity Read ↗

Pleomorphic/solid lobular carcinoma of male breast with PALB2 germline mutation: case report and literature review.Semantic proximity Read ↗

Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results.Semantic proximity Read ↗

Prediction of Specific Survival and Clinicopathological Impact of Somatic PALB2 Mutations and Pathogenic/Likely Pathogenic Variants (PV/LPV) in Breast Cancer: A Cohort Study of 81 Patients.Semantic proximity Read ↗

Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.Semantic proximity Read ↗

PALB2 germline mutations in a large cohort of Middle Eastern breast-ovarian cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.