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Article

PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer.

Breast cancer research : BCR - 1 Jan 2013

Deb Siddhartha, Do Hongdo, Byrne David, Jene Nicholas, Dobrovic Alexander, Fox Stephen B

Abstract excerpt

INTRODUCTION: Although a substantial proportion of male breast cancers (MBCs) are hereditary, the molecular pathways that are activated are unknown. We therefore examined the frequency and clinicopathological associations of the PIK3CA/mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) pathways and their regulatory genes in familial MBC. METHODS: High resolution melting analysis and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23971979
DOI: 10.1186/bcr3463
PMCID: PMC3978692

Genes

BRCA2
AKT1
BRAF
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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