Article
Structure and function of the class C tetracycline/H+ antiporter: three independent groups of phenotypes are conferred by TetA (C).
Molecular membrane biology - 1 Jan 2000
Griffith J K, Cuellar D H, Fordyce C A, Hutchings K G, Mondragon A A
Abstract excerpt
The class C tetracycline/H+ antiporter, TetA(C), confers nine distinct phenotypes in Escherichia coli: resistance to tetracycline, reduced culture density at stationary phase (growth yield), increased supercoiling of plasmid DNA, delayed growth in succinate minimal medium, complementation of potassium uptake defects, increased susceptibility to cadmium, increased susceptibility to fusaric acid, increased...
Topics
- Anti-Bacterial Agents
- Antiporters
- Bacterial Proteins
- Chromosome Mapping
- DNA Mutational Analysis
- DNA, Superhelical
- Drug Synergism
- Frameshift Mutation
- Phenotype
- Structure-Activity Relationship