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Article

Genetic analysis of the tetA(C) gene on plasmid pBR322.

Journal of bacteriology - 1 Dec 1992

McNicholas P, Chopra I, Rothstein D M

Abstract excerpt

The TetA(C) protein, encoded by the tetA(C) gene of plasmid pBR322, is a member of a family of membrane-bound proteins that mediate energy-dependent efflux of tetracycline from the bacterial cell. The tetA(C) gene was mutagenized with hydroxylamine, and missense mutations causing the loss of tetracycline resistance were identified at 30 distinct codons. Mutations that encoded substitutions within putative...

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Identifiers

PMID: 1459940
DOI: 10.1128/jb.174.24.7926-7933.1992
PMCID: PMC207527

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