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Article

Interdomain hybrid Tet proteins confer tetracycline resistance only when they are derived from closely related members of the tet gene family.

Journal of bacteriology - 1 May 1990

Rubin R A, Levy S B

Abstract excerpt

Inner membrane Tet proteins encoded by tet genes in gram-negative bacteria mediate resistance to tetracycline (Tcr) by directing its export. Total sequences for class A, B, and C tet genes demonstrate that their products have a common ancestor, with Tet(A) and Tet(C) being more closely related (78% identical) than either is to Tet(B) (45% identical). The N- and C-terminal halves of Tet(B) and Tet(C) appear to...

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Identifiers

PMID: 2185211
DOI: 10.1128/jb.172.5.2303-2312.1990
PMCID: PMC208863

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