Article
Interdomain hybrid Tet proteins confer tetracycline resistance only when they are derived from closely related members of the tet gene family.
Journal of bacteriology - 1 May 1990
Rubin R A, Levy S B
Abstract excerpt
Inner membrane Tet proteins encoded by tet genes in gram-negative bacteria mediate resistance to tetracycline (Tcr) by directing its export. Total sequences for class A, B, and C tet genes demonstrate that their products have a common ancestor, with Tet(A) and Tet(C) being more closely related (7...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Escherichia coli
- Genetic Complementation Test
- Genetic Vectors
- Genotype
- Molecular Sequence Data
- Multigene Family
- Plasmids
- R Factors
- Repressor Proteins
- Restriction Mapping
- Tetracycline Resistance
- Transcription Factors