Expression of the tetA(C) tetracycline efflux pump in Escherichia coli confers osmotic sensitivity.

doi:10.1111/j.1574-6968.2000.tb09277.x

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Article

Expression of the tetA(C) tetracycline efflux pump in Escherichia coli confers osmotic sensitivity.

FEMS microbiology letters - 1 Sept 2000

Stavropoulos T A, Strathdee C A

Abstract excerpt

Expression of tetA(C) in Escherichia coli confers resistance to tetracycline as well as sensitivity to nickel and cadmium salts, lipophilic chelating agents, and aminoglycoside antibiotics. In this report we determine that high-level expression of tetA(C) also confers an osmotic sensitivity. The osmotic-sensitive phenotype is distinct from the tetracycline-resistant phenotype and can be localized to a domain...

Topics

Antiporters
Bacterial Proteins
Cell Membrane Permeability
Culture Media
Escherichia coli
Nickel
Osmotic Pressure
Phenotype
Protein Structure, Tertiary
Tetracycline Resistance

Source

Open in PubMed

Identifiers

PMID: 10981705
DOI: 10.1111/j.1574-6968.2000.tb09277.x

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