Article
p53 mutations, protein expression and cell proliferation in squamous cell carcinomas of the head and neck.
British journal of cancer - 1 Apr 1995
Nylander K, Nilsson P, Mehle C, Roos G
Abstract excerpt
Thirty-three patients with squamous cell carcinoma of the head and neck region were studied concerning p53 protein expression and mutations in exons 4-9 of the p53 gene using immunohistochemistry, polymerase chain reaction (PCR)-single strand conformation polymorphism analysis and DNA sequencing. Immunoreactivity was found in 64% and p53 gene mutations in 39% of the tumours. Thirty-three per cent of the...
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