Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization.

doi:10.1128/JVI.69.5.2794-2800.1995

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Article

Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization.

Journal of virology - 1 May 1995

Courtois G, Bénit L, Mikaeloff Y, Pauchard M, Charon M, Varlet P, Gisselbrecht S

Abstract excerpt

The myeloproliferative leukemia retrovirus (MPLV) has the v-mpl cellular sequences transduced in frame with the deleted and rearranged Friend murine leukemia virus env gene. The resulting env-mpl fusion oncogene is responsible for an acute myeloproliferative disorder induced in mice by MPLV. v-mp...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA Primers
DNA, Viral
Defective Viruses
Disulfides
Female
Friend murine leukemia virus
Gene Expression Regulation, Viral
Gene Products, env
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia Virus, Murine

Mice

Mice, Inbred DBA

Molecular Sequence Data

Neoplasm Proteins

Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7707501
DOI: 10.1128/JVI.69.5.2794-2800.1995
PMCID: PMC188973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7707501-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization.PMID 7707501Read ↗

Characterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicitySemantic proximity Read ↗

Effects of clinically relevant MPL mutations in the transmembrane domain revealed at the atomic level through computational modeling.Semantic proximity Read ↗

Mpl is activated by dimers of MPN-linked calreticulin mutants stabilized by disulfide bonds and ionic interactionsSemantic proximity Read ↗

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.Semantic proximity Read ↗

Comprehensive mutational analysis of the Moloney murine leukemia virus envelope protein.Semantic proximity Read ↗

Functional interaction between the N- and C-terminal domains of murine leukemia virus surface envelope protein.Semantic proximity Read ↗

Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.Semantic proximity Read ↗

R-Peptide cleavage potentiates fusion-controlling isomerization of the intersubunit disulfide in Moloney murine leukemia virus Env.Semantic proximity Read ↗

Activation of membrane fusion by murine leukemia viruses is controlled in cis or in trans by interactions between the receptor-binding domain and a conserved disulfide loop of the carboxy terminus of the surface glycoprotein.Semantic proximity Read ↗

The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polaritySemantic proximity Read ↗

Function of the cytoplasmic domain of a retroviral transmembrane protein: p15E-p2E cleavage activates the membrane fusion capability of the murine leukemia virus Env protein.Semantic proximity Read ↗

MplK, a natural variant of the thrombopoietin receptor with a truncated cytoplasmic domain, binds thrombopoietin but does not interfere with thrombopoietin-mediated cell growth.Semantic proximity Read ↗

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