Article
Function of the cytoplasmic domain of a retroviral transmembrane protein: p15E-p2E cleavage activates the membrane fusion capability of the murine leukemia virus Env protein.
Journal of virology - 1 Mar 1994
Rein A, Mirro J, Haynes J G, Ernst S M, Nagashima K
Abstract excerpt
In the murine leukemia viruses (MuLVs), the Env complex is initially cleaved by a cellular protease into gp70SU and pre15ETM. After the virus particle is released from the cell, the C-terminal 16 residues are removed from the cytoplasmic domain of pre15E by the viral protease, yielding the mature p15ETM and p2E. We have investigated the function of this cleavage by generating a Moloney MuLV mutant, termed p2E-,...
Topics
- Amino Acid Sequence
- Animals
- Cell Fusion
- Cells, Cultured
- Cricetinae
- Cytopathogenic Effect, Viral
- Membrane Fusion
- Mice
- Microscopy, Immunoelectron
- Molecular Sequence Data