Activation of membrane fusion by murine leukemia viruses is controlled in cis or in trans by interactions between the receptor-binding domain and a conserved disulfide loop of the carboxy terminus of the surface glycoprotein.

doi:10.1128/JVI.75.8.3685-3695.2001

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Article

Activation of membrane fusion by murine leukemia viruses is controlled in cis or in trans by interactions between the receptor-binding domain and a conserved disulfide loop of the carboxy terminus of the surface glycoprotein.

Journal of virology - 1 Apr 2001

Lavillette D, Boson B, Russell S J, Cosset F L

Abstract excerpt

Cell entry of retroviruses is initiated by the recognition of cellular receptors and the subsequent membrane fusion between viral and cellular membranes. These two steps are mediated by the surface (SU) and transmembrane (TM) subunits of the retroviral envelope glycoprotein (Env), respectively. Determinants regulating membrane fusion have been described throughout SU and TM, but the processes coupling receptor...

Topics

Amino Acid Sequence
Disulfides
Gene Products, env
Glycoproteins
Humans
Kinetics
Leukemia Virus, Murine
Membrane Fusion
Models, Biological
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peptide Fragments

Protein Binding

Protein Structure, Tertiary

Receptors, Virus

Recombinant Fusion Proteins

Sequence Alignment

Solubility

Source

Open in PubMed Open full text

Identifiers

PMID: 11264358
DOI: 10.1128/JVI.75.8.3685-3695.2001
PMCID: PMC114860

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