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Article

Characterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicity

1 Aug 1994

Abstract excerpt

v-mpl is a truncated form of a receptor-like chain which belongs to the cytokine receptor superfamily. This sequence has been transduced in the myeloproliferative leukemia virus as an env-mpl fusion gene responsible for an acute myeloproliferative disorder in mice. We constructed a series of viral mutants in the mpl sequence. Analysis of their oncogenic potential in vivo indicated that a critical...

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PMID: 8035524
DOI: 10.1128/jvi.68.8.5270-5274.1994

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