The yeast CLC protein counteracts vesicular acidification during iron starvation.

doi:10.1242/jcs.068403

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Article

The yeast CLC protein counteracts vesicular acidification during iron starvation.

Journal of cell science - 1 Jul 2010

Braun Nikolai A, Morgan Bruce, Dick Tobias P, Schwappach Blanche

Abstract excerpt

Ion gradients across intracellular membranes contribute to the physicochemical environment inside compartments. CLC anion transport proteins that localise to intracellular organelles are anion-proton exchangers involved in anion sequestration or vesicular acidification. By homology, the only CLC protein of Saccharomyces cerevisiae, Gef1, belongs to this family of intracellular exchangers. Gef1 localises to the...

Topics

Ceruloplasmin
Chloride Channels
Glutathione
Homeostasis
Hydrogen-Ion Concentration
Iron Deficiencies
Mutation
Oxidation-Reduction
Protein Conformation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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PMID: 20530571
DOI: 10.1242/jcs.068403
PMCID: PMC2894126

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