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Article

Oxidative stress and iron are implicated in fragmenting vacuoles of Saccharomyces cerevisiae lacking Cu,Zn-superoxide dismutase.

The Journal of biological chemistry - 24 Sept 1999

Corson L B, Folmer J, Strain J J, Culotta V C, Cleveland D W

Abstract excerpt

The absence of the antioxidant enzyme Cu,Zn-superoxide dismutase (SOD1) is shown here to cause vacuolar fragmentation in Saccharomyces cerevisiae. Wild-type yeast have 1-3 large vacuoles whereas the sod1Delta yeast have as many as 50 smaller vacuoles. Evidence that this fragmentation is oxygen-mediated includes the findings that aerobically (but not anaerobically) grown sod1Delta yeast exhibit aberrant vacuoles...

Topics

Aerobiosis
Anaerobiosis
Genotype
Humans
Hydrogen-Ion Concentration
Iron
Microscopy, Electron
Oxidative Stress
Phenotype
Saccharomyces cerevisiae
Superoxide Dismutase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vacuoles

Source

Identifiers

PMID: 10488097
DOI: 10.1074/jbc.274.39.27590

Genes

SOD1

Provenance

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