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Article

Mössbauer and LC-ICP-MS investigation of iron trafficking between vacuoles and mitochondria in vma2ΔSaccharomyces cerevisiae.

The Journal of biological chemistry - 1 Jan 2000

Kim Joshua E, Vali Shaik Waseem, Nguyen Trang Q, Dancis Andrew, Lindahl Paul A

Abstract excerpt

Vacuoles are acidic organelles that store FeIII polyphosphate, participate in iron homeostasis, and have been proposed to deliver iron to mitochondria for iron-sulfur cluster (ISC) and heme biosynthesis. Vma2Δ cells have dysfunctional V-ATPases, rendering their vacuoles nonacidic. These cells have mitochondria that are iron-dysregulated, suggesting disruption of a putative vacuole-to-mitochondria iron trafficking...

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Identifiers

PMID: 33268384
DOI: 10.1074/jbc.RA120.015907
PMCID: PMC7948489

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