Article
Use of a generally applicable tissue factor--dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant.
Blood - 1 Apr 1995
Le D T, Griffin J H, Greengard J S, Mujumdar V, Rapaport S I
Abstract excerpt
The original activated partial thromboplastin time-based assay for activated protein C (APC)-resistant factor Va (FVa) requires carefully prepared fresh plasma and cannot be used in patients receiving warfarin or in patients with antiphospholipid antibodies. A new test is described here that circumvents these limitations and distinguishes without overlap heterozygotes for APC-resistant FVa from persons with...
Topics
- Blood Preservation
- Calcium
- Cryopreservation
- DNA Mutational Analysis
- Factor Va
- Genetic Predisposition to Disease
- Heparin
- Heterozygote
- Humans
- Lupus Coagulation Inhibitor