Article
Whole blood screening test for factor V Leiden using a Russell viper venom time-based assay.
American journal of clinical pathology - 1 Apr 1998
Akhtar M S, Blair A J, King T C, Sweeney J D
Abstract excerpt
Factor V Leiden (FVR506Q) is a genetic defect in the factor V (FV) molecule that confers resistance to proteolysis by activated protein C (APC) and is the most common abnormality detected in patients studied for hereditary thrombophilia. The initial screening test for this abnormality was a compa...
Topics
- Adolescent
- Adult
- Aged
- Aprotinin
- Dose-Response Relationship, Drug
- Factor V
- Female
- Fibrinolytic Agents
- Genetic Testing
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Predictive Value of Tests
- Protein C
- Prothrombin Time