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Article

Whole blood screening test for factor V Leiden using a Russell viper venom time-based assay.

American journal of clinical pathology - 1 Apr 1998

Akhtar M S, Blair A J, King T C, Sweeney J D

Abstract excerpt

Factor V Leiden (FVR506Q) is a genetic defect in the factor V (FV) molecule that confers resistance to proteolysis by activated protein C (APC) and is the most common abnormality detected in patients studied for hereditary thrombophilia. The initial screening test for this abnormality was a comparison of the activated partial thromboplastin time (APTT) in the presence and absence of APC, expressed as a ratio. But...

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Source

Identifiers

PMID: 9535390
DOI: 10.1093/ajcp/109.4.387

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole blood screening test for factor V Leiden using a Russell viper venom time-based assay.PMID 9535390Read ↗

Comparison of an activated partial thromboplastin time with a Russell viper venom time test in screening for factor V(Leiden) (FVR506Q).Semantic proximity Read ↗

A comparison between two activated protein C resistance methods as routine diagnostic tests for factor V Leiden mutation.Semantic proximity Read ↗

Activated protein C resistance assay detects thrombotic risk factors other than factor V Leiden.Semantic proximity Read ↗

Screening for the FV:Q506 mutation--evaluation of thirteen plasma-based methods for their diagnostic efficacy in comparison with DNA analysis.Semantic proximity Read ↗

Determination of activated protein C resistance in anticoagulated and lupus positive patients.Semantic proximity Read ↗

Use of a generally applicable tissue factor--dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant.Semantic proximity Read ↗

The predictability of factor V Leiden (FV:Q(506)) gene mutation via clotting-based diagnosis of activated protein C resistance.Semantic proximity Read ↗

Comparison of three activated protein C resistance tests in the risk assessment of venous thrombosis in non-carriers of the factor V Leiden mutation.Semantic proximity Read ↗

Prothrombin time, activated partial thromboplastin time and dilute Russell's Viper Venom times are not shorter in patients with the prothrombin G20210A mutation, and dilute Russell's Viper Venom time may be longer.Semantic proximity Read ↗

Careful selection of sample dilution and factor-V-deficient plasma makes the modified activated protein C resistance test highly specific for the factor V Leiden mutation.Semantic proximity Read ↗

An improved algorithm for activated protein C resistance and factor V Leiden screening.Semantic proximity Read ↗

Clinical evaluation of a new functional test for detection of activated protein C resistance (Pefakit APC-R Factor V Leiden) at two centers in Europe and the USA.Semantic proximity Read ↗

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