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Article

Mos activates MAP kinase in mouse oocytes through two opposite pathways.

The EMBO journal - 15 Nov 2000

Verlhac M H, Lefebvre C, Kubiak J Z, Umbhauer M, Rassinier P, Colledge W, Maro B

Abstract excerpt

Activation of mitogen-activated protein kinase (MAPK) in maturing mouse oocytes occurs after synthesis of Mos, a MAPKKK. To investigate whether Mos acts only through MEK1, we microinjected constitutively active forms of MEK1 (MEK1S218D/S222D referred herein as MEK*) and Raf (DeltaRaf) into mouse oocytes. In mos(-/-) oocytes, which do not activate MAPK during meiosis and do not arrest in metaphase II, MEK* and...

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Identifiers

PMID: 11080153
DOI: 10.1093/emboj/19.22.6065
PMCID: PMC305841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mos activates MAP kinase in mouse oocytes through two opposite pathways.PMID 11080153Read ↗

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