Article
The HRAS1 minisatellite locus and risk of ovarian cancer.
Cancer research - 15 Jan 2000
Weitzel J N, Ding S, Larson G P, Nelson R A, Goodman A, Grendys E C, Ball H G, Krontiris T G
Abstract excerpt
Approximately 10% of ovarian cancers are due to mutations in highly penetrant inherited cancer susceptibility genes. The highly polymorphic HRAS1 minisatellite locus, located just downstream from the proto-oncogene H-ras-1 on chromosome 11p, consists of four common progenitor alleles and several dozen rare alleles, which apparently derive from mutations of the progenitors. Mutant alleles of this locus represent a...
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