Article
p53 Mutations are present in colorectal cancer with cytoplasmic p53 accumulation.
International journal of cancer - 1 May 2001
Jansson A, Gentile M, Sun X F
Abstract excerpt
Previous studies have shown that nuclear p53 over-expression is an indicator of p53 mutations whereas cytoplasmic p53 accumulation is related to wild-type p53 in several kinds of tumors. Cytoplasmic p53 accumulation has been demonstrated to be an independent prognostic factor in colorectal adenocarcinomas. The purpose was to examine whether mutations occur in cases with p53 accumulated in the cytoplasm and...
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