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Article

p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma.

The American journal of pathology - 1 Sept 1995

Bosari S, Viale G, Roncalli M, Graziani D, Borsani G, Lee A K, Coggi G

Abstract excerpt

p53 accumulation may occur in the nucleus and/or cytoplasm of neoplastic cells. Cytoplasmic accumulation has been reported to be an unfavorable, but not established, prognostic indicator in colorectal cancer. Different types of p53 intracellular compartmentalization could depend either on p53 gene mutations or on the interaction with p53 protein ligands. The purposes of our study were (1) to assess whether the...

Topics

Adenocarcinoma
Colorectal Neoplasms
Humans
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Survival Analysis
Tumor Suppressor Protein p53

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7677190
PMCID: PMC1870957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7677190-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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