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Article

Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-Invariant αβ TCRs Specific for a Conserved Peptide-Qa-1b MHC Class Ib Ligand.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2017

Guan Jian, Yang Soo Jung, Gonzalez Federico, Yin Yuxin, Shastri Nilabh

Abstract excerpt

Ag processing in the endoplasmic reticulum (ER) by the ER aminopeptidase associated with Ag processing (ERAAP) is central to presentation of a normal peptide-MHC class I (MHC I) repertoire. Alternations in ERAAP function cause dramatic changes in the MHC I-presented peptides, which elicit potent immune responses. An unusual subset of CD8+ T cells monitor normal Ag processing by responding to a highly conserved...

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Identifiers

PMID: 28108559
DOI: 10.4049/jimmunol.1600764
PMCID: PMC5321846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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