Article
HIV-1 envelope glycoprotein resistance to monoclonal antibody 2G12 is subject-specific and context-dependent in macaques and humans.
PloS one - 1 Jan 2013
Malherbe Delphine C, Sanders Rogier W, van Gils Marit J, Park Byung, Gomes Michelle M, Schuitemaker Hanneke, Barnett Susan, Haigwood Nancy L
Abstract excerpt
HIV-1 Envelope (Env) protein is the sole target of neutralizing antibodies (NAbs) that arise during infection to neutralize autologous variants. Under this immune pressure, HIV escape variants are continuously selected and over the course of infection Env becomes more neutralization resistant. Many common alterations are known to affect sensitivity to NAbs, including residues encoding potential N-linked...
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