Epstein-Barr virus recombinants with specifically mutated BCRF1 genes.

doi:10.1128/JVI.67.12.7406-7413.1993

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Article

Epstein-Barr virus recombinants with specifically mutated BCRF1 genes.

Journal of virology - 1 Dec 1993

Swaminathan S, Hesselton R, Sullivan J, Kieff E

Abstract excerpt

Epstein-Barr virus (EBV) recombinants with specifically mutated BCRF1 genes were constructed and compared with wild-type BCRF1 recombinants derived in parallel for the ability to initiate and maintain latent infection and growth transformation in primary human B lymphocytes. A stop codon insertio...

Topics

Animals
B-Lymphocytes
Cell Transformation, Viral
Clone Cells
Gene Deletion
Genes, Viral
Herpesvirus 4, Human
Humans
Interferons
Interleukin-10
Leukocytes, Mononuclear
Mice
Mice, SCID
Mutation
Neoplasms, Experimental
RNA, Viral
Recombination, Genetic
Viral Proteins

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