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Article

Functional and physical interactions between the Epstein-Barr virus (EBV) proteins BZLF1 and BMRF1: Effects on EBV transcription and lytic replication.

Journal of virology - 1 Aug 1996

Zhang Q, Hong Y, Dorsky D, Holley-Guthrie E, Zalani S, Elshiekh N A, Kiehl A, Le T, Kenney S

Abstract excerpt

The Epstein-Barr virus (EBV) proteins BZLF1 and BMRF1 are both essential for lytic EBV replication. BZLF1 is a transcriptional activator which binds directly to the lytic origin of replication (oriLyt) and plays a critical role in the disruption of viral latency. The BMRF1 protein is required for viral polymerase processivity. Here we demonstrate that the BMRF1 gene product functions as a transcriptional...

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Identifiers

PMID: 8764021
DOI: 10.1128/JVI.70.8.5131-5142.1996
PMCID: PMC190468

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Functional and physical interactions between the Epstein-Barr virus (EBV) proteins BZLF1 and BMRF1: Effects on EBV transcription and lytic replication.PMID 8764021Read ↗

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