Epstein-Barr virus (EBV) recombinants: use of positive selection markers to rescue mutants in EBV-negative B-lymphoma cells.

doi:10.1128/JVI.65.4.1701-1709.1991

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Article

Epstein-Barr virus (EBV) recombinants: use of positive selection markers to rescue mutants in EBV-negative B-lymphoma cells.

Journal of virology - 1 Apr 1991

Wang F, Marchini A, Kieff E

Abstract excerpt

The objective of these experiments was to develop strategies for creation and identification of recombinant mutant Epstein-Barr viruses (EBV). EBV recombinant molecular genetics has been limited to mutations within a short DNA segment deleted from a nontransforming EBV and an underlying strategy which relies on growth transformation of primary B lymphocytes for identification of recombinants. Thus, mutations...

Topics

Animals
Antigens, Viral
Callitrichinae
Cell Nucleus
Cinnamates
DNA, Recombinant
Drug Resistance, Microbial
Epstein-Barr Virus Nuclear Antigens
Gene Expression
Genes, Viral
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Herpesvirus 4, Human

Hygromycin B

Hypoxanthine Phosphoribosyltransferase

Lymphoma, B-Cell

Mutation

Pentosyltransferases

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 1848303
DOI: 10.1128/JVI.65.4.1701-1709.1991
PMCID: PMC239974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1848303-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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