Article
The only domain which distinguishes Epstein-Barr virus latent membrane protein 2A (LMP2A) from LMP2B is dispensable for lymphocyte infection and growth transformation in vitro; LMP2A is therefore nonessential.
Journal of virology - 1 Nov 1992
Longnecker R, Miller C L, Miao X Q, Marchini A, Kieff E
Abstract excerpt
Using second-site homologous recombination, Epstein-Barr virus (EBV) recombinants were constructed which carry an LMP2A mutation terminating translation at codon 19. Despite the absence of LMP2A or LMP2A cross-reactive protein, the recombinants were able to initiate and maintain primary B-lymphoc...
Topics
- Antigens, Viral
- B-Lymphocytes
- Base Sequence
- Burkitt Lymphoma
- Cell Line, Transformed
- Cell Transformation, Viral
- Codon
- Cross Reactions
- Herpesvirus 4, Human
- Humans
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Recombination, Genetic