Article
Simultaneous mutations in CA and Vif of Maedi-Visna virus cause attenuated replication in macrophages and reduced infectivity in vivo.
Journal of virology - 1 Dec 2005
Gudmundsson Bjarki, Jónsson Stefán Ragnar, Olafsson Oddur, Agnarsdóttir Gudrún, Matthíasdóttir Sigrídur, Georgsson Gudmundur, Torsteinsdóttir Sigurbjorg, Svansson Vilhjálmur, Kristbjornsdóttir Helga Bryndís, Franzdóttir Sigrídur Rut, Andrésson Olafur S, Andrésdóttir Valgerdur
Abstract excerpt
Maedi-visna virus (MVV) is a lentivirus of sheep sharing several key features with the primate lentiviruses. The virus causes slowly progressive diseases, mainly in the lungs and the central nervous system of sheep. Here, we investigate the molecular basis for the differential growth phenotypes of two MVV isolates. One of the isolates, KV1772, replicates well in a number of cell lines and is highly pathogenic in...
Topics
- Animals
- DNA, Viral
- Gene Products, vif
- Genome, Viral
- Macrophages
- Mutation
- Sheep
- Sheep Diseases
- Virus Replication
- Visna-maedi virus