Two amino acid substitutions within the capsid are coordinately required for acquisition of fibrotropism by the lymphotropic strain of minute virus of mice.

doi:10.1128/JVI.66.6.3415-3423.1992

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Article

Two amino acid substitutions within the capsid are coordinately required for acquisition of fibrotropism by the lymphotropic strain of minute virus of mice.

Journal of virology - 1 Jun 1992

Ball-Goodrich L J, Tattersall P

Abstract excerpt

Nucleotide changes at both codons 317 and 321 in the VP2 capsid gene of the immunosuppressive strain of the murine parvovirus minute virus of mice, MVM(i), are required to create a virus capable of growing in A9 fibroblasts. This double mutant virus, ILB1, has growth characteristics very similar to those of the prototype fibrotropic strain MVM(p) in both single- and multiple-round infections of fibroblasts and is...

Topics

Amino Acid Sequence
Animals
Base Sequence
Capsid
Cell Line
DNA Replication
Erythroid Precursor Cells
Humans
Lymphocytes
Minute Virus of Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Organ Specificity

Parvoviridae Infections

Phenotype

Transcription, Genetic

Virion

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1316457
DOI: 10.1128/JVI.66.6.3415-3423.1992
PMCID: PMC241122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1316457-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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