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Article

TGFbeta1 modulates the phenotype of Schwann cells at the transcriptional level.

Molecular and cellular neurosciences - 1 Mar 2002

Awatramani Rajeshwar, Shumas Susan, Kamholz John, Scherer Steven S

Abstract excerpt

We have examined the effects of transforming growth factor beta1 (TGFbeta1) on gene expression in cultured rat Schwann cells (SCs). TGFbeta1 decreased the steady-state mRNA levels of several genes that are expressed by myelinating SCs but had varied effects on the mRNA levels of NCAM, L1, GAP-43, and p75-genes that are expressed by denervated and nonmyelinating SCs. TGFbeta1 antagonized the effects of forskolin...

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PMID: 11906205
DOI: 10.1006/mcne.2001.1094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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