Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice.

doi:10.1016/j.jconrel.2009.12.015

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Article

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice.

Journal of controlled release : official journal of the Controlled Release Society - 5 Jan 2011

Nomura Tetsuya, Abe Yasuhiro, Kamada Haruhiko, Shibata Hiroko, Kayamuro Hiroyuki, Inoue Masaki, Kawara Tomoyuki, Arita Shuhei, Furuya Takeshi, Yamashita Takuya, Nagano Kazuya, Yoshikawa Tomoaki, Yoshioka Yasuo, Mukai Yohei, Nakagawa Shinsaku, Taniai Madoka, Ohta Tsunetaka, Serada Satoshi, Naka Tetsuji, Tsunoda Shin-ichi, Tsutsumi Yasuo

Abstract excerpt

Multiple sclerosis (MS) is an inflammatory demyelinating disease, the pathogenesis of which is related to elevated serum levels of tumor necrosis factor-α (TNF). Although anti-TNF therapy has been tested as a potential treatment for MS, no remission of symptoms was observed. Recent reports indicated that the TNFR1 signal was responsible for the pathogenesis of murine experimental autoimmune encephalomyelitis...

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PMID: 20036293
DOI: 10.1016/j.jconrel.2009.12.015

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