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Article

Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer.

Cancer research - 1 Sept 1993

Bova G S, Carter B S, Bussemakers M J, Emi M, Fujiwara Y, Kyprianou N, Jacobs S C, Robinson J C, Epstein J I, Walsh P C

Abstract excerpt

Allelic loss studies have been instrumental in identifying tumor suppressor gene loci in a variety of cancers. In this study we analyzed prostate cancer specimens from 52 patients for allelic loss using 8 polymorphic probes for the short arm of chromosome 8. Overall, 32 of 51 (63%) informative tumors showed loss of at least one locus on chromosome 8p. The most frequently deleted region is observed at chromosome...

Topics

Alleles
Biomarkers, Tumor
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 8
Homozygote
Humans
Male
Prostate-Specific Antigen
Prostatic Neoplasms

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PMID: 7689419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7689419-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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