Article
In vivo repopulation of cytoplasmically gene transferred hematopoietic cells by temperature-sensitive mutant of recombinant Sendai viral vector.
Biochemical and biophysical research communications - 28 Sept 2007
Yoshida Kumi, Yonemitsu Yoshikazu, Tanaka Sakura, Yoshida Shuro, Shibata Satoko, Kondo Haruhiko, Okano Shinji, Ishikawa Fumihiko, Akashi Koichi, Inoue Makoto, Hasegawa Mamoru, Sueishi Katsuo
Abstract excerpt
Recent clinical studies revealed 'proof of concept' of gene therapy targeting hematopoietic stem cells (HSCs) to treat hematopoietic disorders. However, vector integration-related adverse events of retroviral vectors have slowed progress in this field. As an initial step to overcoming this hurdle, we examined the potential of an improved cytoplasmic RNA vector, temperature-sensitive mutant non-transmissible...
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