Mutation frequency in human blood cells increases with age.

doi:10.1016/0921-8734(95)00019-3

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Article

Mutation frequency in human blood cells increases with age.

Mutation research - 1 Oct 1995

Akiyama M, Kyoizumi S, Hirai Y, Kusunoki Y, Iwamoto K S, Nakamura N

Abstract excerpt

Using either the colony formation assay or flow cytometry, it is feasible to measure the frequency of rare mutant lymphocytes or erythrocytes in human peripheral blood. Accordingly, we have investigated the mutant cell frequencies of the hypoxanthine-guanine phosphoribosyltransferase and T-cell r...

Topics

Adolescent
Adult
Aged
Child
Child, Preschool
Chromosome Aberrations
Clone Cells
DNA Replication
Erythrocytes
Female
Glycophorins
Hematopoietic Stem Cells
Humans
Hypoxanthine Phosphoribosyltransferase
Infant
Infant, Newborn
Male
Middle Aged

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