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Article

Influence of protein surface charge on the bimolecular kinetics of a potassium channel peptide inhibitor.

Biochemistry - 13 Jul 1993

Escobar L, Root M J, MacKinnon R

Abstract excerpt

This study investigates the influence of a through-solution electrostatic interaction on the kinetics of ion channel blockade by the high-affinity peptide inhibitor Lq2. Membrane patches containing many Shaker K+ channels were removed from Xenopus oocytes and placed in a rapid perfusion chamber. Lq2 association and dissociation rate constants were determined from the relaxations to equilibrium blockade following...

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Identifiers

PMID: 7687466
DOI: 10.1021/bi00078a024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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