Article
Mechanism of charybdotoxin block of a voltage-gated K+ channel.
Biophysical journal - 1 Oct 1993
Goldstein S A, Miller C
Abstract excerpt
Charybdotoxin block of a Shaker K+ channel was studied in Xenopus oocyte macropatches. Toxin on rate increases linearly with toxin concentration in an ionic strength-dependent fashion and is competitively diminished by tetraethylammonium. On rate is insensitive to transmembrane voltage and to K+...
Topics
- Animals
- Binding, Competitive
- Biophysical Phenomena
- Biophysics
- Charybdotoxin
- Drosophila
- Female
- Ion Channel Gating
- Kinetics
- Membrane Potentials
- Mutation
- Oocytes
- Peptides
- Potassium Channel Blockers
- Potassium Channels
- Recombinant Proteins
- Scorpion Venoms
- Shaker Superfamily of Potassium Channels