Article
Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy.
Journal of virology - 1 Mar 1994
Richman D D, Havlir D, Corbeil J, Looney D, Ignacio C, Spector S A, Sullivan J, Cheeseman S, Barringer K, Pauletti D
Abstract excerpt
Drug susceptibility and mutations in the reverse transcriptase (RT) gene were analyzed with 167 virus isolates from 38 patients treated with nevirapine, a potent nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) RT. Resistant isolates emerged quickly and uniformly in all pati...
Topics
- Antiviral Agents
- Base Sequence
- CD4-Positive T-Lymphocytes
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Genotype
- HIV Core Protein p24
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Leukocyte Count
- Molecular Sequence Data
- Mutagenesis