Article
Genetic susceptibility in familial multiple sclerosis not linked to the myelin basic protein gene.
Lancet (London, England) - 8 May 1993
Rose J, Gerken S, Lynch S, Pisani P, Varvil T, Otterud B, Leppert M
Abstract excerpt
The myelin basic protein (MBP) gene is a candidate locus for disease susceptibility in familial multiple sclerosis. Amplification of a polymorphic tetranucleotide repeat region immediately 5' to MBP exon 1 demonstrated the presence of eight different alleles among members of 14 multiplex multiple...
Topics
- Alleles
- Base Sequence
- Chromosome Mapping
- DNA
- Disease Susceptibility
- Gene Frequency
- Genes, Dominant
- Genes, Recessive
- Genetic Linkage
- Humans
- Incidence
- Lod Score
- Magnetic Resonance Imaging
- Models, Genetic
- Molecular Sequence Data
- Multiple Sclerosis
- Myelin Basic Protein
- Polymerase Chain Reaction