Article
No linkage or association of the nitric oxide synthase genes to multiple sclerosis.
Journal of neuroimmunology - 3 Sept 2001
Modin H, Dai Y, Masterman T, Svejgaard A, Sørensen P S, Oturai A, Ryder L P, Spurkland A, Vartdal F, Laaksonen M, Sandberg-Wollheim M, Myhr K M, Nyland H, Hillert J
Abstract excerpt
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of unknown etiology. Nitric oxide (NO) is a free radical that participates in a variety of biological processes. It is an important mediator in the immune response. Several studies indicate involvement of NO in the pathogenesis of MS. We studied five markers within the three NO synthase genes with regards to...
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