Article
Linkage analysis of candidate myelin genes in familial multiple sclerosis.
Neurogenetics - 1 Sept 1999
Seboun E, Oksenberg J R, Rombos A, Usuku K, Goodkin D E, Lincoln R R, Wong M, Pham-Dinh D, Boesplug-Tanguy O, Carsique R, Fitoussi R, Gartioux C, Reyes C, Ribierre F, Faure S, Fizames C, Gyapay G, Weissenbach J, Dautigny A, Rimmler J B, Garcia M E, Pericak-Vance M A, Haines J L, Hauser S L
Abstract excerpt
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. A complex genetic etiology is thought to underlie susceptibility to this disease. The present study was designed to analyze whether differences in genes that encode myelin proteins influence susceptibility to MS. We performed linkage analysis of MS to markers in chromosomal regions that include the genes encoding myelin...
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