Article
An immortalized cystic fibrosis tracheal epithelial cell line homozygous for the delta F508 CFTR mutation.
American journal of respiratory cell and molecular biology - 1 May 1993
Kunzelmann K, Schwiebert E M, Zeitlin P L, Kuo W L, Stanton B A, Gruenert D C
Abstract excerpt
The development of transformed human airway epithelial cell lines has been important in advancing the understanding of the biochemical and genetic mechanisms underlying the cystic fibrosis (CF) defect. Since the most common mutation associated with CF is a phenylalanine deletion at position 508 (delta F508) in the CF transmembrane conductance regulator (CFTR) gene, a transformed airway epithelial cell line...
Topics
- Adult
- Base Sequence
- Biological Transport
- Blotting, Southern
- Cell Line, Transformed
- Cell Transformation, Viral
- Chlorides
- Cyclic AMP
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator