Article
Transformation of airway epithelial cells with persistence of cystic fibrosis or normal ion transport phenotypes.
Methods in enzymology - 1 Jan 1990
Yankaskas J R, Boucher R C
Abstract excerpt
These studies demonstrate the feasibility of transforming human airway epithelial cells while inducing only modest changes in function. Features central to the pathophysiology of cystic fibrosis, i.e., abnormal regulation of a chloride permeability in the apical cell membrane, appear to be preser...
Topics
- Antigens, Polyomavirus Transforming
- Biological Transport
- Cell Line
- Cell Transformation, Viral
- Cystic Fibrosis
- Electric Conductivity
- Epithelium
- Humans
- Intercellular Junctions
- Phenotype
- Reference Values
- Respiratory Physiological Phenomena
- Respiratory System
- Simian virus 40