Article
CFTR gene transfer to lung epithelium--on the trail of a target cell.
Current gene therapy - 1 May 2002
O'Dea S, Harrison D J
Abstract excerpt
Cystic fibrosis (CF) is a lethal inherited disease that afflicts up to 1 in 2,500 people in the western world. Since 1989, when mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene were identified as responsible for the disease, intense effort has been applied to the development of replacement gene therapy strategies to cure CF. Problems with basic gene delivery techniques along with...
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