Article
Altered UV resistance and UV mutational spectrum in repair-proficient murine fibroblasts expressing endonuclease V.
Mutation research - 1 Mar 1998
Kusewitt D F, Dyble J, Sherburn T E, Ryan S L, Ji J Y
Abstract excerpt
In previously reported studies, we transfected repair-proficient murine fibroblasts with the denV gene of bacteriophage T4 and showed that expression of encoded endonuclease V markedly enhanced cyclobutane pyrimidine dimer (CPD) repair and reduced the frequency of ultraviolet radiation (UV)-induc...
Topics
- Animals
- Cell Survival
- Cells, Cultured
- DNA Repair
- Deoxyribonuclease (Pyrimidine Dimer)
- Endodeoxyribonucleases
- Fibroblasts
- Gene Expression
- Hypoxanthine Phosphoribosyltransferase
- Mice
- Mutagenesis
- Mutation
- Radiation Tolerance
- Ultraviolet Rays