Article
(6-4) photoproducts and not cyclobutane pyrimidine dimers are the main UV-induced mutagenic lesions in Chinese hamster cells.
Mutation research - 1 Jan 1992
Zdzienicka M Z, Venema J, Mitchell D L, van Hoffen A, van Zeeland A A, Vrieling H, Mullenders L H, Lohman P H, Simons J W
Abstract excerpt
A partial revertant (RH1-26) of the UV-sensitive Chinese hamster V79 cell mutant V-H1 (complementation group 2) was isolated and characterized. It was used to analyze the mutagenic potency of the 2 major UV-induced lesions, cyclobutane pyrimidine dimers and (6-4) photoproducts. Both V-H1 and RH1-26 did not repair pyrimidine dimers measured in the genome overall as well as in the active hprt gene. Repair of (6-4)...
Topics
- Animals
- Base Sequence
- Cell Line
- Cricetinae
- Cricetulus
- Cyclobutanes
- DNA
- DNA Repair
- Hypoxanthine Phosphoribosyltransferase
- Molecular Sequence Data
- Mutation