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Article

Expression of simian virus 40 large T (tumor) oncogene in mouse chondrocytes induces cell proliferation without loss of the differentiated phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993

Mallein-Gerin F, Olsen B R

Abstract excerpt

We have infected primary embryonic mouse limb chondrocytes with a retrovirus carrying simian virus 40 early regions and have obtained a monoclonal mouse chondrocyte line, MC615, that was able to grow on culture dishes for at least 7 months and 20 passages. MC615 cells show expression of simian virus 40 large T (tumor) antigen and express markers characteristic of cartilage in vivo, such as types II, IX, and XI...

Topics

Animals
Animals, Newborn
Antigens, Polyomavirus Transforming
Blotting, Northern
Blotting, Western
Cartilage
Cell Differentiation
Cell Division
Cell Transformation, Viral
Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Collagen

Electrophoresis, Polyacrylamide Gel

Fetus

Kinetics

Liver

Mice

Oncogenes

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 7682698
DOI: 10.1073/pnas.90.8.3289
PMCID: PMC46285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7682698-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Expression of simian virus 40 large T (tumor) oncogene in mouse chondrocytes induces cell proliferation without loss of the differentiated phenotype.PMID 7682698Read ↗

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