Levels of hypoxanthine phosphoribosyltransferase RNA in human cells.

doi:10.1016/0014-4827(90)90301-p

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Article

Levels of hypoxanthine phosphoribosyltransferase RNA in human cells.

Experimental cell research - 1 Feb 1990

Steen A M, Luthman H, Hellgren D, Lambert B

Abstract excerpt

The gene for the purine salvage enzyme hypoxanthine phosphoribosyltransferase (HPRT) is expressed at a low level in many cells. As is the case with several other "housekeeping genes," thorough studies of hprt gene regulation have been hampered by the low levels of its mRNA. We have used RNA/RNA hybridization in solution to determine the concentration of hprt-RNA in human cells. The sensitivity and specificity of...

Topics

Amnion
Cell Line, Transformed
Cells, Cultured
Clone Cells
Fibroblasts
Glioma
Humans
Hypoxanthine Phosphoribosyltransferase
Lesch-Nyhan Syndrome
Lymphocytes
Melanoma
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuroblastoma

Nucleic Acid Hybridization

Phytohemagglutinins

RNA

RNA Probes

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 1688803
DOI: 10.1016/0014-4827(90)90301-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1688803-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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