Article
Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan.
Cancer letters - 18 Jan 2008
Sakuma Yuji, Matsukuma Shoichi, Yoshihara Mitsuyo, Sakurai Shinji, Nishii Masahiro, Kishida Takeshi, Kubota Yoshinobu, Nagashima Yoji, Inayama Yoshiaki, Sasaki Takeshi, Nakamura Yoshiyasu, Miura Takeshi, Kameda Yoichi, Tsuchiya Eiju, Miyagi Yohei
Abstract excerpt
About 10-40% of testicular germ cell tumours (TGCTs) have been reported to have activating c-kit gene mutations. A European study group has reported that most bilateral TGCTs from European patients have c-kit mutations at codon 816, although few unilateral cases harbour the mutations. This implies that the presence of a c-kit mutation in a unilateral TGCT predicts the development of TGCT in the contralateral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.