Article
Lack of effect of inhibitors of DNA synthesis/repair on the ionizing radiation-induced chromosomal damage in G2 stage of ataxia telangiectasia cells.
International journal of radiation biology - 1 Sept 1994
Antoccia A, Palitti F, Raggi T, Catena C, Tanzarella C
Abstract excerpt
The relationship between the repair processes occuring at the G2 phase of the cell cycle and cytogenetic damage in ataxia telangiectasia (AT) cells was studied. Lymphoblastoid cells derived from normal, heterozygote AT (HzAT) and three AT patients were exposed to X-rays or fission neutrons and post-treated with inhibitors of DNA synthesis/repair, such as inhibitors of DNA polymerases alpha, delta and epsilon...
Topics
- Ataxia Telangiectasia
- Chromosome Aberrations
- DNA Repair
- DNA-Directed DNA Polymerase
- G2 Phase
- Humans
- Hydroxyurea
- Mutation
- Nucleic Acid Synthesis Inhibitors