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Article

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

The EMBO journal - 1 May 1993

Molinete M, Vermeulen W, Bürkle A, Ménissier-de Murcia J, Küpper J H, Hoeijmakers J H, de Murcia G

Abstract excerpt

The zinc-finger DNA-binding domain (DBD) of poly (ADP-ribose) polymerase (PARP, EC 2.4.2.30) specifically recognizes DNA strand breaks induced by various DNA-damaging agents in eukaryotes. This, in turn, triggers the synthesis of polymers of ADP-ribose linked to nuclear proteins during DNA repair. The 46 kDa DBD of human PARP, and several derivatives thereof mutated in its first or second zinc-finger, were...

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Identifiers

PMID: 8491199
DOI: 10.1002/j.1460-2075.1993.tb05859.x
PMCID: PMC413432

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Source receipt: pubmed, retrieved 7 Sept 2026.

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