Article
Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.
The EMBO journal - 1 May 1993
Molinete M, Vermeulen W, Bürkle A, Ménissier-de Murcia J, Küpper J H, Hoeijmakers J H, de Murcia G
Abstract excerpt
The zinc-finger DNA-binding domain (DBD) of poly (ADP-ribose) polymerase (PARP, EC 2.4.2.30) specifically recognizes DNA strand breaks induced by various DNA-damaging agents in eukaryotes. This, in turn, triggers the synthesis of polymers of ADP-ribose linked to nuclear proteins during DNA repair...
Topics
- Alkylation
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Line
- Cells, Cultured
- DNA
- DNA Repair
- Escherichia coli
- Haplorhini
- Humans
- Methylnitronitrosoguanidine
- Molecular Sequence Data
- Mutation
- Poly(ADP-ribose) Polymerase Inhibitors